Chapter 1660: Chapter 1664: Major Discovery! (Fifth Update)
Indeed!
Qi Kai and Yang Lan had question marks in their eyes throughout the journey.
They couldn’t understand why Chen Cang thought this sly old fox was a good person!
No matter how you look at him, he doesn’t seem like a good person, does he?
After returning, Chen Cang said to the two, "Let’s go, back to the lab first, I have something to say!"
Upon hearing this, Qi Kai and Yang Lan immediately nodded. Although they didn’t know what was going on, they still followed him.
The system has already provided several plans for Chen Cang now!
All need to be tried.
But he is limited in ability alone; both must cooperate to operate together.
Fortunately, both of them are experienced veterans, and all the experiments were done quickly!
On the night Tethys left.
Chen Cang began the separation according to the system prompts.
He found that Lewy bodies as intermediate products should be present in body fluid biomarkers!
However, according to special detection methods, he found that it is not entirely similar!
If that’s the case...
Chen Cang suddenly said to Yang Lan and Qi Kai, "Actually... Lewy bodies are not a single substance!"
"They should contain multiple substances. We should look for commonalities in the cerebrospinal fluid, urine, and saliva!"
As soon as he said this, the two felt it was feasible and continued their frantic extraction and research.
Chen Cang increasingly felt that five days was too short!
But on the fourth day!
The composition of Lewy bodies was successfully deciphered: eosinophilic inclusions composed of neurofilaments, tubulin, ubiquitin, and a special substance!
The discovery of this special substance immediately excited Chen Cang!
Because he found that it is a soluble protein expressed pre-synaptically and around the nuclei in the central nervous system, closely related to the pathogenesis and related dysfunction of Parkinson’s disease.
This magnificent discovery directly made everyone in the office ecstatic!
This is almost a milestone victory!
After discovering this special substance.
Chen Cang continued to detect according to the system’s auxiliary methods.
One after another, special potential biomarkers were discovered!
The most important is one, a special information symbol transferred between neurotransmitters.
Everyone discovered that this was α-synuclein!
The discovery of this α-synuclein advanced the experiment to a new stage.
Because, through fluid marker checks, this substance was found in cerebrospinal fluid, saliva, and urine!
However, Chen Cang and others discovered during the research.
Parkinson’s rats had reduced saliva secretion; this might be related to α-synuclein damage affecting and controlling the salivary gland autonomic nerves!
Then!
Chen Cang immediately began research on Parkinson’s patients with single symptoms, discovering this α-synuclein suddenly found not simply a positive correlation!
For a moment, it seemed the research on α-synuclein had hit a bottleneck again!
That day, Chen Cang found that the rats could no longer provide research for their experiments; he contacted Wu Hui and directly received the patient’s blood!
Then, Chen Cang linked it with Tethys’ words!
Perhaps, Parkinson’s is not a degenerative disease.
Thinking of this possibility, Chen Cang suddenly discovered.
This Tethys is entirely a fraud.
Tethys clearly wants to circumvent him.
Because after examining the results, Chen Cang found:
Parkinson’s disease is a neurodegenerative disease but not simply a degenerative disease; a key feature of this disease is the accumulation of damaged α-synuclein in Parkinson’s patients.
So, how is the damaged α-synuclein produced?
The complexity and monotony of scientific research nearly drove Chen Cang to collapse!
This period, to avoid wasting any time, Chen Cang rested very little each day.
Relying entirely on potion to endure!
Seeing this, Yang Lan and Qi Kai couldn’t help but admire.
Perhaps Chen Cang’s success is by no means accidental!
With such an effort level, coupled with excellent personal abilities and talent, it’s impossible not to achieve results!
Just as Chen Cang’s experiment fell into a stalemate.
Chen Cang suddenly had a brainwave and began researching books, studying α-synuclein itself!
This research did have some different results.
That is, generally speaking, α-synuclein is a normal substance.
But why do T cells increase inside the body?
What activated him?
Thinking of this, Chen Cang’s mind began to spin wildly.
α-synuclein!
Parkinson’s!
T cells!
Immune response!
...
Various pieces of information kept mixing in the mind.
Again and again!
Chen Cang began to speculate that normal α-synuclein cannot possibly cause an immune response in the human body?
Could it be...
Parkinson’s is actually an immune response?
If this is the case, the immune response caused by α-synuclein accumulation is like an autoimmune reaction?
Thinking of this, Chen Cang suddenly felt this is very frightening!
Next, he hurriedly began checking the literature!
Then, through experimentation, he injected large amounts of extracted α-synuclein into normal rats.
But...
No reaction!
This signal transmission factor didn’t elicit a response in the rat’s nervous system.
T cells were normal!
Additionally, there were no Parkinson’s responses!
Why is that?
Now, in the last few hours of the system.
Chen Cang suddenly discovered a special substance.
This substance is amazingly similar to α-synuclein.
But it’s not α-synuclein!
Chen Cang quickly asked Yang Lan to come over to assist in research!
This research.
Left everyone in shock!
Yang Lan said with some delight, "Professor Chen, I say... you might be about to discover a miracle!"
Chen Cang was instantly taken aback, "What’s going on?"
Qi Kai also widened his eyes, filled with curiosity and anticipation!
Yang Lan wrote out the chemical equation for the item.
"This is a damaged α-synuclein that can become a folded α-synuclein!"
"This thing might very well be what you said could induce a cellular immune response!"
After hearing this, Chen Cang’s eyes lit up!
He suddenly said, recalling various information:
"Yes! Normally, neurons can clear these abnormal α-synuclein!"
"But when neurons can no longer clear abnormal α-synuclein, autoimmune reactions occur in Parkinson’s disease."
"So, the α-synuclein in Lewy bodies is probably a damaged α-synuclein!"
At this moment, Chen Cang suddenly remembered Tethys’ words!
He smiled slightly: "Now you know Professor Tethys is not a bad person, right?"
Qi Kai and Yang Lan were instantly taken aback.
Chen Cang slowly said: "Just like Tethys said!"
"Parkinson’s disease is partially an autoimmune disease!"
"And what induces this autoimmune disease is this folded α-synuclein!"
There was one thing Chen Cang didn’t say: that is... Tethys might not have known Parkinson’s is an autoimmune disease!
Otherwise, he wouldn’t have shared this information with me.
...
...
ps: Five updates delivered, a bit late, thank you for everyone’s support.